Dipyridamole Discussion

Dear Dryeyezone friends and others...Let's continue the discussion here =)

testing =)

Firstly I think it's important we do a small introduction into what these dipyridamole drops are and what they do for those not aware. These drops have been produced by a not for profit organisation called MedInSight, it aims to reduce the physical symptoms (dry eye, stinging, burning) from corneal diseases such as pingucela, pterygium, conjunctivitis, vascularisation etc. It also aims to cosmetically improve the eye by reducing the severity and appearance of pingucela, pterygium and red irritated veins.

To see the patent visit: google.com/patents/WO2014141079A1?cl=en

To see 'before and after' images of a lady who used these drops in a clinical trial visit: eurekalert.org/multimedia/pub/71033.php

For more on MedInSight visit: medinsight.org

At the time of posting you can only obtain the drops by purchasing here: buyldn.com/dipyridamole-eye-drops.html

If you do choose to purchase the drops, please fill in the survey provided by MedInSight, this will help them with vital research: docs.google.com/forms/d/1Vnfp8MNeJHg21GIbFfKcDE28Py4jU0IsZ39MNg2XN8Y/viewform?c=0&w=1

You will also be provided with a discount coupon for your next purchase.

Disclaimer: everyone using this forum, unless introduced as otherwise, is a consumer of these drops and do not represent MedInSight at any professional level. We can only base our knowledge of these drops on our own research and individual experiences. For any questions on the science or production of these drops please contact Shira at MedInSight, email can be accessed at the MedInSight website.

I would like to ask anyone using the drops to please report back here. Your feedback is so helpful to not only inform others, but to pass on to MedInSight for their research as well. I've been using these drops for four months now, the progress is slow but steady. My eyes are definitely less dry (even glossy on waking) and the veins have got thinner and has gone from a harsh red to a light pink. My pings appear smaller too.

Dear Claire

How refreshing to hear from you! I attempted to register with DEZ a month ago but never heard back from Rebecca. Much kudos goes out to this wonderful new forum to facilitate discussing the drops

I've been using them for four weeks now and although my symptoms have noticeably lessened, I have yet to experience any aesthetic improvements. I'm ever so curious Claire to know how many times a day you administer the drops, and beyond the pings whether you have any other veins that have become visible since developing dry eye?

Admittedly your story reads so similarly to my own, although I have several angry - tortuous even - scleral veins that I'm terribly self conscious about. I've tried everything for the past year now, many drops of which have developed additional veins and damaged my tear film. The dipyridamole drops are the only ones that don't seem to make things worse which is definitely a good sign!

E x

Also Claire not to be a pest but how long did it take you to see results from the dipyridamole drops? Would you say the veins have shrunk or just that the colour of them have faded? x

I'm sorry to hear you've been through the same eye troubles as me! It's horrible and finding an answer really isn't easy. Through my eye conditions (blepharitis and evaporative dry eye) and previous drop abuse my eyes became congested with lots of thin red veins and my pingucela, which was originally very mild, became very inflamed.

To put your mind at ease, when speaking to Shira (shira @ medinsight.org) she tells me the average time most users see an aesthetic improvement is 6 - 8 weeks. For me, it took around the 3 week mark to notice the veins looking less red. I'm now at the four month mark and I can honestly say there is a difference from when I first started using them. My veins have become thinner, they are now a very watered down pink instead of the harsh red they used to be. I think how it's working for me is the veins aren't reducing in length but just getting so thin they are almost on the point of disappearing. My pingucela is hardly visible anymore, the yellow is much milder and it's shrunk in size.

I first started using the drops twice a day, when I felt more comfortable with them (and reassured they weren't going to irritate my eyes further!) I upped my dose to 4 - 6 times a day, but I'd only do this if you feel comfortable with doing so. It reassures me that these drops are preservative free, and that dipyridamole has a history of safe usage for other purposes.

I also understand about being wracked with worry that the drops don't work. I have to say it's a very slow, gradual process (if you read the patent it makes it sound like some cases were resolved within weeks, I think it's safer to have realistic expectations as, for me, it's taken months to get to the stage I'm at now). Try not to despair and keep trooping on with the drops. The fact the dryness has lessened is a positive sign! It sometimes took weeks between seeing another burst of improvement with my eyes, what I'd advise if getting a close friend - or family member - to give you a weekly or monthly report on how your eyes are looking. Sometimes we are so wrapped up in it we can't see it changing, it's good to get an objective point if view!

Tomorrow I'll post some before and after pics so you can see the difference.

Thanx for setting up this forum. Glad we have a avenue to discuss these eye drops and keep up with the product. I havent started the drops yet because of the cost, but as soon i do, i will start posting monthly results to the forum.

Claire

It's absolutely lovely to hear from you. Thanks for the update on the drops. My veins seem to have materialised after overusage of drops (especially night ointments), particularly any containing boric acid. I, like yourself, left a job I'd worked so hard to snare, and I have stopped socialising completely. To this day maintaining my eyes is a full time obsession as, for the longest time (since last summer) my eyes have progressively gotten worse.

Fantastic news that the drops are treating you so well!
At what point did you up your dosage to 4-6 times a day? That could be the key for me as I'm not currently having any adverse reactions to them either. Is it best to gradually up them or do it overnight?

Do your eyes sting upon application of the drops - Shira kindly informed me that there are two solutions, one which contains saline and citric acid, and I wondered if one might be more effective than the other despite the two having the same concentration of dipyridamole.

Are/were all your veins nearer the surface of your eye? As many of mine are deep in the sclera and it's these that I'm most worried about And like myself have you found a gradual improvement in the symptoms of blepharitis/dry eye?

Sorry for all the questions - conversing with you is like a lifeline for me

Elizabeth x

Hi,

How strange that our cases are so so similar! On an emotional level I really relate and emphasise with what you're going through.

After a month I started increasing the dosage, it was more an overnight decision than a gradual build up!

Yes I have veins in my right eye that seem to be below the surface on my eye. It really upset me when I noticed it had happened as my thoughts were they are harder to get rid of. Through using these drops the amount of veins has decreased (they were little thin ones) and they are less noticeable.

Ah, yes I realised there were two different solutions for these drops. The first batch I bought didn't irritate my eyes at all, but the second were more yellow and felt stronger (maybe that's the saline and citric acid one) which does irritate my eye on application. I try to remember thought that these drops are not like 'get the red out' drops that work as a vasoconstrictor, but are a vasodilator. While vasoconstrictors shrink the eye blood vessels short term they expand out afterwards and can cause long term damage. A vasodilator works in reverse, it increases ocular blood flow to make the veins redder but it's only short term as they start shrinking after.

I don't feel like I have dry eye anymore, for the first time in a long time I have sleep in my eyes. I keep on top of my blepharitis regardless by using tea tree foam on my eyelashes, I also keep up the omega 3s - just because I want to give my eyes the best chance possible!

I don't mind you asking any questions, I'm happy to help you. I feel I'm two thirds of the way there now. It's taken a while so I know how daunting it all is! I still have days where I think they look awful (compared to how white and clear they used to be!) but I know it's just my negative state of mind and they are getting better. To the point it's not even noticeable to others now.

Claire

Thanks for your response.... I really appreciate the pep talk and sound advice

I wonder about the tea tree foam - in the event of it getting in your eyes, does it not sting like mad? How do you rinse it off? I found warm compresses made both my eyes and under eye area much worse. I travelled all the way to Moorfields the other day to facilitate getting a prescription for Azithromycin to tackle my MGD as I've tried unsuccessfully for many months now to be prescribed antibiotics with local GPs - who seem hellbent on prescribing me more preservative laden eye drops.

What other supplements do you recommend? I've tried Lutein, Turmeric, ALA, Taurine and numerous others but have been advised only Omegas would prove beneficial.

I don't suppose you have developed several floaters like myself?

E x

Hi,

I get a brand of tea tree foam from Boots which has tea tree and witch hazel in it, I find it isn't that strong and doesn't irritate my eyes that much if some accidentally gets into my eye. I wash my face first and put some foam on wet hands just to dilute it a bit more. I just keep my eyes firmly shut and wash over my eyelashes - rinsing well with cold water (just splash tons of it over my face Tea tree is a natural antibacterial remedy and I find it much cheaper than buying brands like ocusoft, I guess it's about whatever you're comfortable using!

Vitamin wise I used sea buckthorn oil (with omega 3 in it, find link below) for a while. It's specially formulated for dry eyes but it is very expensive. Now my budgets a bit tighter I just go for high strength omega 3 and bilberry and eyebright capsules.

I haven't developed floaters, but I'm sure there's probably info on the dry eye forum to read up about it.

I actually changed my GP to one I felt was caring enough and open minded enough to help me by any means possible. I asked her about doxycycline, it's quite a popular antibiotic which is prescribed for a number of things including MGD. Maybe ask your doctor about it and how it was recommend by people who are suffering the same condition. If your doctor won't consider it maybe an opthmologist will?

bodykind.com/Supplements/Pharma-Nord/product/1459-Omega-7-Sea-Buckthorn-Oil-150-Capsules.aspx?Referer=Froogle_Omega-7-Sea-Buckthorn-Oil-150-Capsules&utm_source=froogle&utm_medium=price%20comparison&utm_campaign=Omega-7-Sea-Buckthorn-Oil-150-Capsules&gclid=CMqdj_LoqMUCFULJtAodQSoA1Q

Claire,

Thank you so much for sharing. We really appreciate you taking the lead in this treatment. Can you answer a few questions for me?

Are you following the recommended 2 week shelf life after opening the bottle?

Also, would you say your eyes are clear to the point where you are no longer self-conscious when looking other people in the eye?

Lastly, do you feel the vein thnning is permanent or will it get worse once you go off the drops?

I am so excited to hear about your positive results so far!

Claire

Well done. Thank you.

I think there are several pharmacies in different countries making these drops since the patent was published.

I think they are in US and Canada.

I too am doing great with them.

Ted

Hi,

I try and keep it within the 2 week recommended period, as I feel they are more effective when they are first opened. However, I know they are pricey and it is fine to use them beyond 2 weeks if you keep the bottle stored in a cool place like the fridge.

I would say my eyes have gone to the point of being unnoticeable to others. To me, close up, there's still some veins I wish were gone but it's no where near as obvious as they were before.

My eyes have never regressed - I think the veins are thinner for good unless I do something really bad to upset them!

Ted - I wasn't aware they were being sold anywhere other than on the buyldn website. To you know the names of the US and Canada pharmacies? If so, could you mention them on here? Thanks!

Are there any reports of long term adverse effects when using dipyridamole drops?

Xdip - to my knowledge, no. But I think that might be a question to Shira - as they would be more aware about any research conducted. Email is given above.

Please let us know if there is!

I'm visiting my eye consultant next week, he'll examine my eyes and tell me if there are any changes. I'll report any comments back here.

Claire

Your advice is absolutely invaluable! Would love to see your before and after photos When you administer your drops, do you block your tear duct? And were you ever woken up by the dryness of your eyes in the night prior to taking the drops - this is something that's slowly improving for me now.

I tried Omega 7 for 2.5 months but haven't seen a marked improvement to justify the cost of them. I use cold compresses in sterile cucumber water which helps on the comfort front, but I'm keen not to dilute the concentration of the drops in the eye so I tend to space things apart a bit.

Hi!

No I don't block my tear ducts (I imagine that's be tricking to do while applying the drops!) but when I administer them I close my eyes immediately after putting them in, and for about 2 - 3 minutes, with my eyes closed, I roll my eyes to ensure the drops spread everywhere. Sounds strange I know!

I did have a few sleepless nights due to how dry and raw my eyes felt, but thankfully I no longer suffer from that.

If you PM me your email address I'll send some over. For some reason I cannot post them on here, it just won't accept them.

Hi
Just started using the dipyridamole drops twice a day.
Have dry eyes, red veins and pings.
No improvements as yet!!
Just to say Claire has been very helpful with her advice, it's great to talk to someone in the same position.
Hopefully these drops are a way forward.

I was hoping Rebecca unlock topic. But she's not manifested, so let's go.

Suzy. I used approximately 7 drops per day. While I used the eyedrops the eye irritated a little bit, getting noticeably redder. But after I stop using, felt that there was an improvement in appearance. Nothing miraculous. But improved.

I think you're wearing very little. I used 7 drops for 1 month approximately.

Someone asked about side effects from prolonged use.
I think that there is no scientific answer to that yet.
Not even the developer possess double-blind studies about it.
So I believe that we should be aware that we are our own guinea pigs.

Andre - really glad to hear the drops have taken some effect. It's a real shame we can't continue the old thread but good that we can least discuss it on here.

How long are you planning to use the drops for? And how has your eyes improved? Reduction of veins or just a decrease in the redness?

Claire, i bought four more drops. I plan use seven drop per day for two months. After this, i plan use three drops per day, one in the morning and two before i sleep.

It helped me with redness and morning pain (and morning redness too).

Is dificult to explain how it helped with the redness.
I think the inflammation is de cause of my redness.
As my tears dont give a effective protection for my cornea, the agression suffered during the day (wind, dust, air conditioner, etc) cause inflammation and redness.
I think the drops helps to decrease inflamatory response. Consequently, i have less redness (and pain too).

To explain how i see redness decrease.
When your eyes are very inflamed you have more redness and more veins.
With less inflamation, the eyes get more white and some veins disapear.
This is what i feel with the drops.

As my eyes continue without protection, this sensation varies accord with the air humidity of day. However, i feel my eyes are better.

It help me a lot with morning redness and pain.
Until now, everything i use to sleep dont help me in the morning.
Preservative-free drops worsened my eyes. Saline help if my eyes is not very inflamed. Autologous serum drops have helped me a lot. But i have to use this one hour before i sleep.

With the Dipy (i will call the drops with this name - Dipy - Is more easy to type) i found a great combination. I use the autologous serum drops during whole day and DIPY before sleep and after waking up.

This way my eyes feel better in the morning. This is the unique substance that not bothering my eyes during the night. And i wake up with fresh eyes sensation. With no sand sensation on eyes.

This is the good part.

In the beggining it was not so easy.
In the first day my eyes were red and swollen.
I continued using the drops. (by my own risk)
In the second week, the eyes were less red. And i felt less burning and "sand sensation".
After one month of use, i saw the improvements.
In the last two days, the bottle was with little quantity of drops. Then i used this only at the night, before sleep, and at morning, after wake up. In this way i discovered the combination that i said above.

This is a little of my history with Dipy.
In this moment i am in dallas, but this is another history.

Ps1: I have used seven drops per day because it have fifteen days until expire after you open the bottle. And this way, you will reach the same substance quantity used in a mini-research that i read.

Ps2: I have Dryeyes due the lasik surgery. In addition to the methods that i have told in this post, i use other tools for my dry-eyes,

Ps3: I Always have a doctor that accompanies my "experiences".

Ps4: I am sleepy and i did not do the text revision.

Hi Andre!

Thanks for your informative reply. My eyes got worse from using other drops too, even preservative free ones. I was at wits end until I tried the dipyridamole drops! I hope the redness keeps on getting better for you.

Ok, just had my appointment with my eye consultant to check the health of my eyes since using the drops. I've come back all clear and he's even discharged me! My eye pressure is fine, my tear film/glands are in working order, he even noted the inflammation has died down and my eyes don't look inflamed anymore. Big relief! I only told him what I was using after he gave me an overall summary of how things were looking. He said he never heard of using dipyridamole before but will research into it. He said it looks like it's helping but couldn't make any further comment on it (for professional reasons I imagine).

So good news from me!

I am soo happy to have found this forum!

I am a 26 year old male, I have been suffering from severely inflamed pinguecula's in both eyes for 5 years now

Andrea and Claire, thank you soo much for posting the information you have so far.

Claire congratulations on your eye health check up yesterday, I was very happy to hear that.

I am very anxious to order these eye drops, but nervous about us being the "guinea pigs" with these drops...short term, long term possible complications....ugh.

Everyone please continue to update and share your progress with these eye drops. I can't believe these actually might be the miracle drops I've been searching for for the last 5 years.